Reactive chemicals are sensitive to either friction or shock or they react in the presence of air, water, light, or heat. Explosive chemicals decompose or burn very rapidly when subjected to shock or ignition. Reactive and explosive chemicals produce large amounts of heat and gas; they are extremely dangerous.
Examples of reactive compounds include the following:
| REACTIVE CLASSIFICATION | CHEMICAL EXAMPLES |
| Acetylenic compounds | Acetylene |
| Azides | Benzenesulfonyl azide |
| Azo compounds | Azomethane |
| Chloro/perchloro compounds | Lead perchlorate |
| Fulminates | Copper (II) fulminate |
| Nitro compounds | Nitromethane |
| Nitrogen-containing compounds | Silver amide |
| Organic peroxide formers | Diethyl ether |
| Picrates | Picric acid (dry) |
| Peroxides | Diacetyl peroxide |
| Strained ring compounds | Benzvalene |
| Polymerizable compounds | Butadiene |